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In an animal model (C57Bl/6 mice) of type 2 diabetes mellitus induced by a high-fat diet (HFD), Luís et al. showed that 8-prenylnaringenin normalized the expression of Galectin-3 (Gal3), a protein overexpressed during the diabetic state, and was strongly associated with oxidative stress in the liver and kidneys of diabetic mice. In addition, it reduced 3-nitrotyrosine (a marker of cell damage), inflammation, and nitric oxide (NO) production, and promoted the production of glycation end products (AGEs). Increased levels of AGEs in response to diabetic inflammation have been reported to play a role in tissue stiffness, increased blood pressure, heart failure, and endothelial dysfunction. This polyphenol may, therefore, be a potential therapeutic agent against diabetes mellitus.
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