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Research on the health effects of hesperidin is fairly limited. However, there's some evidence that hesperidin may offer certain benefits.2 Here's a look at some key study findings.
Consumption of citrus fruit has been associated with a reduced risk of cardiovascular disease. Several clinical trials exploring hesperidin's effect on cardiovascular disease markers have yielded mixed results.
A 2016 study published in the American Journal of Clinical Nutrition, for instance, investigated the effect of six weeks of hesperidin supplementation on blood vessels in men and women who were overweight. While there was no significant change in flow-mediated dilation (a test used to measure artery, or endothelial, function), the subset of people with relatively healthy endothelial function saw further significant improvement in endothelial function after eating a high-fat meal compared to those who took a placebo.
In addition, regular hesperidin consumption may decrease blood pressure and improve blood vessel function, suggests a study conducted with overweight men published in the American Journal of Clinical Nutrition in 2011. After four weeks of daily consumption of orange juice or a hesperidin beverage, participants' diastolic blood pressure was significantly lower, and their endothelial function (after eating a meal) had significantly improved.
Hesperidin also shows promise for people who have had a heart attack, suggests a study published in the Journal of the American College of Nutrition in 2015. For the study, people who'd experienced a heart attack took either a hesperidin supplement or a placebo for four weeks. At the study's end, those who took the hesperidin had significantly decreased levels of some inflammatory markers.
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