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Hesperetin is a flavanone, that is, mainly found in citruses, such as lemons, limes, tangerines, and other fruits, such as grapes. It has been observed that hesperetin and its metabolites have an important effect in the decrease of inflammatory responses through various mechanisms.
Hesperetin is known as hesperidin and as neohesperidose, and as it is bound to glucose and to rhamnose, it can form isomeric configurations that can provide sweet and bitter flavors in fruits where they are found.
In the early studies, hesperetin was reported to possess vitamin-like activity and to decrease capillary permeability, leakiness, and fragility. Hesperetin deficiency has been linked with abnormal capillary leakiness and pain in the hands, feet, and leg cramps at night. Over the past decades, extensive research was conducted on the bioactivity of hesperetin, and numerous biological properties, principally anticancer and anti-inflammatory activities have been identified. Hesperetin is also a promising anticancer agent whose activity has been reported in multiple types of cancers, including gastric, colon, breast, lung, and liver cancers.
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