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Rhoifolin was also isolated from Citrus grandis (L.) Osbeck leaves, and its insulin-mimetic action was reported by Rao et al. in an in vitro study using differentiated 3T3-L1 adipocytes cells. It was found to act via promoting adiponectin secretion, the phosphorylation of IR-β, and GLUT4 translocation, which are considered to be critically involved in diabetic complications. The action of rhoifolin against these genes may provide novel targets for combating insulin-resistance-associated diseases.
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