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The main role of Diosmin

Diosmin, a flavonoid commonly found in citrus fruits, a derivative of Hesperidin, has been widely used and prescribed for more than 30 years as a VAD in Chronic Venous Disease for its phlebotonic effect known to improve venous tone, stabilize capillary permeability and increase lymphatic drainage, and also for its well-established safety profile. It has been recently shown that a possible mechanism of action involved in the improvement of Chronic Venous Disease after oral Diosmin treatment may be a significant decrease in proinflammatory mediators such as IL-6 and TNF- and pro-angiogenetic factors.

For overcoming Diosmin’s poor bioavailability following oral ingestion, several attempts have been made, of which the reduction in particle size (i.e., micronization) is the most commonly used, to increase flavonoids’ absorption and bioavailability. Although the plasma levels are generally improved after the oral administration of micronized Diosmin, concentrations are often low and highly different across published studies. A micronized flavonoid fraction (MPFF), consisting of 90% diosmin and 10% hesperidin, has been successfully used in Europe as a drug or nonprescription dietary supplement for the treatment of chronic venous insufficiency with a treatment regimen of 1000 mg/day given in two divided doses.

Benepure is able to offer different specifications of Diosmin, including regular 80mesh, micronized 10um and 5um and also MPFF containing 90% diosmin and 10% hesperidin. In case of any demand, please feel free to contact with us.

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