Sulfasalazine(Salicylazosulfapyridine)

Product Name:Sulfasalazine(Salicylazosulfapyridine)

Chemical Name:5-(p-(2-pyridylsulfamoyl)phenylazo)salicylic acid

CAS Number: 120011-70-3

Molecular Formula:C18H14N4O5S

Molecular Weight:398.4

Specification: USP/EP

Clinical Applications:

Sulfasalazine is used in the treatment of inflammatory bowel disease, including ulcerative colitis and Crohn’s

disease. The mode of action of Sulfasalazine (SSZ) or its metabolites, 5-aminosalicylic acid (5-ASA) and

sulfapyridine (SP), is still under investigation, but may be related to the anti-inflammatory and/or

immunomodulatory properties that have been observed in animal and in vitro models, to its affinity for

connective tissue, and/or to the relatively high concentration it reaches in serous fluids, the liver and

intestinal walls, as demonstrated in autoradiographic studies in animals. In ulcerative colitis, clinical studies

utilizing rectal administration of SSZ, SP, and 5-ASA have indicated that the major therapeutic action may

reside in the 5-ASA moiety.