First used therapeutically in the 1960s, diosmin is widely available in dietary supplement form. In many cases, diosmin is taken in combination with hesperidin, another citrus fruit flavonoid. A supplement known as "micronized purified flavonoid fraction", or MPFF, is a combination of diosmin with hesperidin,1 typically in a 9:1 ratio. Diosmin can also be produced by extracting hesperidin from citrus rinds and modifying its components.
A number of studies suggest that diosmin may help with certain health conditions. Here's a look at some key findings on diosmin and its potential health benefits:
Chronic Venous Disease
Chronic venous disease refers to conditions that affect the veins of the legs. For instance, chronic venous insufficiency is a condition in which the veins do not effectively return blood from the legs to the heart, and is associated with varicose veins, ankle swelling, and nighttime leg cramping.
Diosmin and hesperidin may help to treat chronic venous disease, according to a study published in the journal Phlebology.3 The study included 136 people with chronic venous disease. After treatment with micronized diosmin and hesperidin (or other treatments or a placebo), reductions in fluid volume in the leg were more frequent in those taking diosmin and hesperidin.
Several studies indicate that diosmin and other flavonoids may be beneficial in the treatment of hemorrhoids. For instance, a study published in Techniques in Coloproctology evaluated the effectiveness of diosmin, hesperidin, and troxerutin in people with acute hemorrhoids.4 After 12 days of treatment, pain, bleeding, and the proportion of people who reported persisting swelling and thrombosis decreased significantly in those taking the flavonoid mixture.
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