Product classification：WHAT WE DO> Citrimore®>
Product Name: Diosmetin
CAS Number: 520-34-3
Raw material main source: Sichuan, Jiangxi, Zhejiang, Guangxi, Hunan, etc.
Appearance: Yellow fine powder
Botanical Source: Citrus limon L.
Diosmetin is an O-methylated flavone found in vetch and various citrus fruits; it exhibits antioxidative, anti-inflammatory, and anti-osteoporotic activities. In animal models of AAPH-induced oxidative stress, diosmetin decreases generation of ROS and increases levels of superoxide dismutase, catalase, and glutathione peroxidase. Diosmetin also decreases amylase, lipase, TNF-α, IL-1β, IL-6, and iNOS in animal models of pancreatitis. Additionally, this compound increases activation of PKC, ERK1/2, and p38 MAPK, inducing osteoblastic differentiation in vitro.